Clinical implementation of tumor profiling in an enterprise-wide, unselected cancer patient population has yet to be reported. . Deletion of TRF1 in type II AECs for up to 9 months resulted in short telomeres and lung remodeling characterized by increased numbers of type II AECs, α-smooth muscle actin+ mesenchymal cells, collagen deposition, and accumulation of senescence-associated β-galactosidase+ lung epithelial cells. Deletion of TRF1 in collagen-expressing cells caused pulmonary edema, but not fibrosis. H-Index、 These results demonstrate that prolonged telomere dysfunction in type II AECs, but not collagen-expressing cells, leads to age-dependent lung remodeling and fibrosis. Ram P. Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew L. Donne, Gary Green, Janet L. La, Jason R. Rock, Mark R. Looney, Paul J. Wolters, Lynette M. Sholl, … , Neal I. Lindeman, Laura E. MacConaill, Yan Xu, … , Barry R. Stripp, Jeffrey A. Whitsett, Julian Mackay-Wiggan, … , Angela M. Christiano, Raphael Clynes, Qian Li, … , Brent R. Stockwell, Jian Wang, Ram P. Naikawadi, … , Mark R. Looney, Paul J. Wolters, Published June 23, 2019, by JCI Insight staff, Published March 16, 2017; First published December 8, 2016, Institutional implementation of clinical tumor profiling on an unselected cancer population, https://doi.org/10.1172/jci.insight.87062, Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis, https://doi.org/10.1172/jci.insight.90558, Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata, https://doi.org/10.1172/jci.insight.89790, Inhibition of neuronal ferroptosis protects hemorrhagic brain, https://doi.org/10.1172/jci.insight.90777, Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis, https://doi.org/10.1172/jci.insight.86704, American Society for Clinical Investigation. New England Journal of Medicine, We utilized single-cell RNA sequencing (scRNA-seq) to identify epithelial cell types and associated biological processes involved in the pathogenesis of IPF. Journal Impact Trend Forecasting System displays the exact community-driven Data without secret algorithms, hidden factors, or systematic delay. Nature Reviews Drug Discovery, 学術雑誌人気のリサーチおよび Ratio of a journal's items, grouped in three years windows, that have been cited at least once vs. those not cited during the following year. The insights gained from this study will advance our knowledge of the post-ICH cell death cascade and be essential for future preclinical studies. SPC-Cre TRF1fl/fl mice will be useful for assessing cellular and molecular mechanisms of lung fibrosis mediated by telomere dysfunction.
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